Oxygen Control & Monitoring in Pharmaceuticals & Medical Gases

Electrochemical oxygen analyzers have a vital role to play in the safe production of pharmaceuticals. Usage of solvents and powders in huge quantities causes considerable risk of explosions. Eliminating oxygen using a blanket gas, usually nitrogen, decreases the possibility of a fire or an explosion.

Oxygen Control and Monitoring in Pharmaceuticals and Medical Gases

Pharmaceuticals and specialty chemicals are normally prepared in batches by combining many components in a reactor. These reactors differ in size ranging from tabletop glass jars to large glass-lined or stainless steel vessels with a blender (like a giant household food blender). The vessel will be subjected to nitrogen blanketing before as well as during batch production. It is necessary for the oxygen levels to be monitored always to ensure operator and plant safety. Previously, companies just permanently supplied N2 to the process and did not care about the oxygen level. However, N2 is a consumable with an associated cost that can and must be reduced. This is realized by monitoring the oxygen level and stopping the supply of N2 when the O2 levels are safe.

Inertization in Centrifuges

Organic solvents are often used in pharmaceutical production processes. For controlling the resulting vapor mixtures — which can cause an explosion — scraper centrifuges will be purged with nitrogen before starting production. Consequently, the centrifuge remains in a nitrogen atmosphere during production. In order to compensate for air ingress through leaks, oxygen analyzers are used for controlling the N2 injection.

Upon performing inertization with pressure, the oxygen content of the exhaust air stream is determined using a portable measuring device such as the GPR-1200 series on the initial start-up of the inertization.

For setting up an installation with pre-installed online oxygen measurement, the O2 content of the exhaust air stream is continuously measured, and if there is excess oxygen, for example, about 6%, nitrogen is added until the oxygen content has been reduced back to 4% to meet the LEL of the process.

Blanketing in Centrifuges

Application/Service Measurement Gas Stream Suggested Analyzer
Oxygen monitoring of centrifuges during drying process. 0 to 2% O2
0 to 21% O2
N2 GPR-1900
GPR-2500

Blanketing of Production Process

Application/Service Measurement Gas Stream Suggested Analyzer
Oxygen analysis in nitrogen carrier-gas with solvents present. 0 to 5% O2
0 to 21% O2
N2 various solvents GPR-1900
GPR-2500

Personnel Protection

Application/Service Measurement Gas Stream Suggested Analyzer
Monitoring of oxygen deficiency. 19.5% O2 CO2, air GPR-35

Oxygen Analyzers and Sensors for Medical Breathing Gases and Respiratory Therapy

Analytical Industries manufactures oxygen sensors for the most sophisticated life-support systems employed in emergency medicine, intensive care and also, in outpatient care such as devices for anesthesia, respiratory treatment, lung function, ventilation technology, and incubators.

Oxygen Analyzers and Sensors for Medical Breathing Gases and Respiratory Therapy

Ensuring patient safety
The series of medical oxygen sensors and devices available from Analytical Industries are FDA-approved and therefore health centers can rely on them with confidence.

Outstanding long-term stability — at a reasonable cost​
Analytical Industries medical sensors satisfy the stringent quality demands of healthcare. The company provides gas sensors versions with extended service life to meet the rising cost and maintenance challenges of hospitals.

FDA-compliant quality
The quality system of Analytical Industries is built on decades of supplying oxygen sensors to critical healthcare applications. Every single sensor goes through several inspections throughout the manufacturing process and also automated final inspection in which all sensor details are logged into the central database.

Customized OEM medical sensors
Analytical Industries regularly develops custom-made gas sensors for healthcare OEM customers, customized to their designs and specifications.

Handheld Oxygen Analyzers for Medical Gases

Handheld Oxygen Analyzers for Medical Gases

Analytical Industries-2000 and Analytical Industries-2000 Palm O2

  • Handheld oxygen analyzer for medical gases
  • Cost-effective O2 Sensors
  • Operates with no need for maintenance
  • Easy verification of O2 levels in clinics
  • Low cost of ownership
  • Up to 32 months sensor life
  • FDA approved
  • Maintenance free

This information has been sourced, reviewed and adapted from materials provided by Analytical Industries Inc.

For more information on this source, please visit Analytical Industries Inc.

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