The industry-wide shift to A2L refrigerants, pushed by changing environmental legislation, has had a wide range of effects on the global heating, ventilation, and air conditioning (HVAC) sector.
Verticals other than traditional building cooling, such as commercial and transportation refrigeration and data center cooling, are about to transition to A2L frameworks. These shifts toward A2L have also resulted in additional thermal and safety considerations for HVAC/R system design.
Data Center Expansion Driving Cooling Growth
With the rapid growth of AI and other computing-intensive systems, the demand for data center infrastructure has increased exponentially in recent years.
These expansion activities are matched by a sustained emphasis on energy efficiency and consumption reduction, notably in thermal management systems, which account for a sizable amount of overall power use. These new systems use A2L refrigerants to meet global climate change laws.
Integrating A2L refrigerants into data center cooling infrastructure, notably in Computer Room Air Conditioning (CRAC) and Computer Room Air Handling (CRAH) systems, requires completely redesigning safety-critical components. Chief among these is modern leak detection systems that can operate reliably in high-humidity, thermally active situations.
Smaller Commercial Refrigeration Systems Leveraging A2L
Commercial refrigeration systems frequently require high-capacity compressors to handle the tremendous pressures required by carbon dioxide (CO2)-based refrigerant loops, which can reach up to 150 bar (≈2100 psi).
While CO2 has a low global warming potential (GWP), its high operating pressure needs a strong mechanical design and specialized components, making it less suitable for compact systems like those in convenience stores.
Ammonia (NH3) remains viable due to its high thermodynamic efficiency and negligible GWP. However, its toxicity and severe safety regulations limit its use in consumer-facing or mobile refrigeration systems.
To meet safety requirements such as UL60335-2-40, A2L-based systems must include integrated leak detection devices. Sensor placement and performance are crucial, especially near the evaporator coil, which is susceptible to refrigerant leakage caused by heat cycling, condensation, and mechanical stress.
The mobile nature of commercial refrigeration systems, frequently relocated across retail locations, also adds fluctuation in ambient temperatures and airflow patterns, affecting sensor calibration and reliability.
Engineers must consider these dynamic elements when building leak detection systems to ensure robust performance across a wide range of operational settings while remaining compliant and minimizing false positives.
Transport Refrigeration Shows Expansion of A2L Ecosystem
Refrigerated transport solutions are essential to the logistics industry. They decrease food waste and keep other commodities safe during transit, such as refrigerated medical supplies.
These transportation methods rely on temperature-controlled vehicles like trucks, ships, and containers, with built-in refrigeration systems that keep them cool during the journey.

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Transport refrigeration systems require precise temperature control and continued monitoring to operate their complicated thermal cycles while ensuring cargo integrity and regulatory compliance.
As the industry transitions to low global warming potential (GWP) refrigerants for ecologically responsible operations, performance demand for electronics in the system continues to climb.
Unlike residential refrigerators, transport refrigeration systems must be designed to endure vibration, environmental extremes, and power variations. The demanding environment may influence essential monitoring and control systems. Failures can cause product spoilage, financial loss, and safety risks.
Transport refrigeration systems require dependable electronic components that provide accurate monitoring and control even in harsh operating environments to meet environmental demands and escalating performance expectations.
Gas detection sensors that work with A2L refrigerants are a potential solution for the recent use of low global warming potential refrigerants.
The Sensata Resonix™ RGD leak detection sensor can identify even low-level leaks of slightly flammable A2L gases by constantly monitoring the ambient air's acoustic resonance, supporting safety and environmental objectives. To ensure corrosion resistance, the sensor has been tested under a wide range of conditions, including severe vibration and acidic salt fog environments.
Thermal Drift and System-Level Impacts in A2L-Based HVAC Architectures
The switch to A2L refrigerants requires a reevaluation of pressure and temperature thresholds in HVAC system designs. These mildly flammable refrigerants usually run at high discharge temperatures, which may increase thermal drift, especially in high-side pressure sensing and control components.
High-pressure cutoff switches, which are critical for operational safety and compliance with regulatory standards (such as UL and IEC), are particularly vulnerable.
Excessive thermal drift can cause premature or delayed actuation, reducing the system reliability and increasing the likelihood of false trips or failure to engage in fault conditions.
This challenge is compounded by the increased emphasis on energy efficiency as a competitive differentiator. Erroneous pressure measurements caused by thermal instability can disrupt control logic, and prevent compressors, fans, and pumps from performing optimally.
This results in suboptimal system performance, elevated energy consumption, and increased operational costs due to unnecessary cycling or maintenance interventions.
Precision in thermal management is especially important in applications that require strict environmental control (such as data centers, pharmaceutical storage, or process cooling). In these situations, low-drift pressure sensors and integrated smart control systems are critical.
Enhanced thermal stability ensures precise real-time data capture, allowing for more responsive and intelligent system behavior via sophisticated control algorithms.
Looking Ahead for A2L System Developments
As A2L and A3 refrigerant-based HVAC systems spread throughout global markets and expand into new verticals, it becomes increasingly clear that this transition represents the start of a long period of iterative design refinement rather than a single market change.
The changing regulatory landscape and refrigerant properties drive ongoing innovation in system architecture, component integration, and control methodologies.
Due to their significant contribution to commercial building energy consumption, HVAC systems remain a focus area in global energy reduction measures. This typically ranges between 40% and 60% of overall usage, presenting HVAC platforms as a main target for increased efficiency and reduced carbon impact.
Using new refrigerants alters thermal operating conditions, prompting a reevaluation of system components such as compressors, expansion valves, sensors, and control logic.
Engineers must evaluate the consequences of changing temperature profiles to ensure system performance remains within optimal parameters. This involves preserving thermal stability, limiting drift in sensor devices, and ensuring interoperability with smart control systems that aim to maximize energy economy.
Adaptive design techniques will define the next stage of HVAC innovation. In this approach, component selection and system calibration are constantly updated to fulfill the dual needs of regulatory compliance and high-efficiency operation.

This information has been sourced, reviewed and adapted from materials provided by Sensata Technologies, Inc.
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