May 27 2010
A state-of-the-art software package, known as MS Workstation 7, has been released by the new Chemical Analysis Division of Bruker Dynamics for the recently acquired 3x0 portfolio of GC triple-quadrupole (GC-QQQ) type of mass spectrometers.
This software incorporates the Schedule Multiple Reaction Monitoring (s-MRM) feature for facilitating the technique’s development, maintaining and data reducing tasks to challenge the multi-component techniques.
Customarily GC-QQQ mass spectrometers are being utilized for such multiplexed, targeted analysis by virtue of their extremely good selectivity, high sensitivity, large dynamic range, and low quantization limits obtained by using the quadrupole MS instruments’ multiple reaction monitoring (MRM) feature. However, the sample matrix’s complexity and the analytes’ chromatographic peak widths and the instrument’s cycle time restricts the number of compounds that can be monitored during a chromatographic run using a triple quadrupole MS, especially during fast GC operations.
Bruler has created the s-MRM method to counter the challenges due to the multi-residue and complex techniques. The method is now available through the MS Workstation 7, an enhanced s-MRM functionality that lowers the quantity of concurrent MRM transitions, which helps in monitoring the MRMs during their likely retention times only. This software permits the optimization of dwell times and instrument cycle times for providing maximum sensitivity for reproducible and accurate results. The s-MRM method enables increased MRM transitions monitoring during an analysis and is also capable of tackling the rigors of present multi residue, fast GC techniques and at the same time maintain the maximum data quality.
According to Bruker Chemical Analysis Division’s President Collin D’Silva, Bruker ensured the high quality and performance of the GC-QQQ-MS, ICP-MS, and GC instruments of the former Varian Inc, before acquisition. He added that the company is focused on speeding up research and development, besides the development and validation of applications, to render the company’s chemical analysis products to emerge as more valued resources for users.
Source: http://www.bdal.com