The CrystalSCAN from H.E.L Group is a benchtop, automated parallel crystallization monitoring platform designed to determine solubility curves and metastable zone width (MSZW) across multiple samples, supporting the optimisation of crystallization processes. The system supports up to eight independently controlled reactors, each equipped with H.E.L's CrystalEYES crystallization monitoring technology.
In addition to automated stirring, heating and cooling of each sample, CrystalSCAN supports automated solvent and anti-solvent addition, enabling independent sample dilution at the end of each cycle. This allows dissolution and nucleation points to be determined under different experimental conditions, providing data for constructing solubility curves and evaluating MSZW.
Combining parallel experimentation with detailed process measurements, CrystalSCAN accelerates crystallization process development and optimisation.
Features and Options
Vessel Types and Volumes / Test Cells
- Fully stirred reaction vessels from 2 mL to 500 mL.
- Configurations supporting up to eight independently controlled reactors, with 8-reactor systems accommodating vessels up to 120 mL and 4-reactor systems accommodating vessels up to 500 mL.
- Compatible with different reactor types, including vials, reaction tubes, customised vessels and high-pressure vessels.
Temperature Control
- Temperature range from −60°C to +200°C, depending on the selected circulator and configuration.
- A separate heating and cooling zone for each reactor provides independent temperature control, allowing temperature differences exceeding 100°C between reactors.
Reagent Addition
- Automated dilution and solvent addition.
Control Options
- Independent sample control. Eight reactors with separate stirring and temperature-controlled zones.
Sensor
- CrystalEYES near-infrared (NIR) turbidity probes enable real-time detection of dissolution and nucleation points for solubility and crystallization studies.
Stirring Available
- Independent stirring, measured and controlled.
- Magnetic stirring, with automatic de-coupling detection.
- Suspended mechanical stirring for efficient mixing.
- Optional overhead stirring.
- Stirrer geometry designed to minimize damage to crystals.
Intelligent Software Control and Analysis
- H.E.L's WinISO software provides automated data logging, multi-step experimental procedures, parameter control and feedback loops, with an intuitive interface for configuring and monitoring crystallization experiments.
Safety Features
- Automatic, user-configurable reaction detection and shutdown procedures to ensure user safety.
- Automatic hardware and software fail-safes on every system.
